– Non-small cell carcinoma, favor adenocarcinoma (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous clusters of malignant cells with enlarged nuclei, irregular nuclear membranes, prominent nucleoli, and moderate amounts of delicate cytoplasm. The cell block section shows similar findings. These findings are diagnostic of a non-small cell carcinoma with features suggestive of an adenocarcinoma. Clinical and radiologic correlation is suggested.
– Adenocarcinoma, consistent with lung origin (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous clusters of malignant cells with enlarged nuclei, irregular nuclear membranes, prominent nucleoli, and moderate amounts of delicate cytoplasm. The cell block section shows similar findings with areas of malignant gland formation and *** patterns. These findings are those of adenocarcinoma. An immunohistochemical stain for TTF-1 is positive, consistent with lung origin. Clinical and radiologic correlation is suggested.
– Non-small cell carcinoma, favor squamous cell carcinoma (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous clusters of malignant cells with hyperchromatic, pleomorphic nuclei and dense cytoplasm. The cell block shows similar findings. These findings are diagnostic of a non-small cell carcinoma with features suggestive of squamous cell carcinoma. Clinical and radiologic correlation is suggested.
– Squamous cell carcinoma (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous clusters of malignant cells with hyperchromatic, pleomorphic nuclei and dense cytoplasm. The cell block shows similar findings with focal areas of keratinization. These findings are diagnostic of squamous cell carcinoma. Clinical and radiologic correlation is suggested.
– High-grade carcinoma with neuroendocrine features (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous clusters of malignant cells with enlarged nuclei, irregular nuclear membranes, prominent nucleoli, and moderate amounts of delicate cytoplasm. The cell block section shows similar findings with solid groups of tumor and areas of necrosis. Numerous mitotic figures are identified. An immunohistochemical stain for synaptophysin is positive. These findings are those of high grade carcinoma with neuroendocrine features. This may represent adenocarcinoma and/or large cell neuroendocrine carcinoma. A component of small cell carcinoma cannot be excluded on this limited sample. Definitive classification is deferred to the anticipated resection section. Clinical and radiologic correlation is suggested.
– Neuroendocrine tumor, consistent with carcinoid tumor (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing clusters and single cells with round nuclei and stippled chromatin. The cell block shows similar findings. There is no increased mitotic activity, necrosis, or high-grade cytologic features. These findings are diagnostic of a low-grade neuroendocrine tumor and favor typical carcinoid. Clinical and radiologic correlation is suggested.
– Small cell carcinoma (see comment)
COMMENT: The aspirate smears are abundantly cellular, showing numerous crushed and discohesive cells with hyperchromatic nuclei and scant cytoplasm. There is prominent nuclear molding. The cell block shows similar findings with areas of necrosis. Numerous mitotic figures are identified. These findings are diagnostic of small cell carcinoma. Clinical and radiologic correlation is suggested.
Last updated: September 2, 2019