– Metastatic high-grade carcinoma, consistent with Mullerian origin (see comment)

COMMENT: The cell block shows malignant cells with high N:C ratios, irregular hyperchromatic nuclei, and prominent nucleoli. These cells stain positive for Ber-EP4, PAX8, WT-1, and strongly diffusely for P53 and P16. The morphologic and immunoprofile supports a diagnosis of high-grade serous carcinoma of tubo-ovarian origin.  Clinical and radiographic correlation is recommended.